Timeline: iPSCs—The First Decade
نویسندگان
چکیده
Research into induced pluripotent stem cells (iPSCs) has expanded at a remarkable pace in the decade since Shinya Yamanaka and Kazutoshi Takahashi first reported their groundbreaking discovery in 2006. This Timeline highlights the key events in the development of this field, including basic insights into the production of iPSCs and how they have been applied to improve our understanding and treatment of human disease.
منابع مشابه
A Cell-ebration of Induced Pluripotency
In 2006, Shinya Yamanaka and Kazutoshi Takahashi reported their landmark discovery of induced pluripotent stem cells (iPSCs) in Cell. Their demonstration that pluripotent stem cells could be generated by expressing a cocktail of four defined factors in mouse fibroblasts transformed our view of cell fate and its reversibility. At the time, we were excited to be publishing a paper that posed new ...
متن کاملسلولهای بنیادی چندتوان القا شده در پژوهش و درمان بیماریها: مقاله مروری
Differentiated cells can change to embryonic stem cells by reprograming. Generation of induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative and personalized medicine. iPSCs can self-renew and differentiate into many cell types. iPSC cells offer a potentially unlimited source for targeted differentiation. Through the expression of a set of transcription factors, iP...
متن کاملMental Timeline in Persian Speakers’ Co-speech Gestures based on Lakoff and Johnson’s Conceptual Metaphor Theory
One of the introduced conceptual metaphors is the metaphor of "time as space". Time as an abstract concept is conceptualized by a concrete concept like space. This conceptualization of time is also reflected in co-speech gestures. In this research, we try to find out what dimension and direction the mental timeline has in co-speech gestures and under the influence of which one of the metaphoric...
متن کاملInherited heart disease – what can we expect from the second decade of human iPS cell research?
Induced pluripotent stem cells (iPSCs) were first generated 10 years ago. Their ability to differentiate into any somatic cell type of the body including cardiomyocytes has already made them a valuable resource for modelling cardiac disease and drug screening. Initially human iPSCs were used mostly to model known disease phenotypes; more recently, and despite a number of recognised shortcomings...
متن کاملEstablishment and the importance of chicken pluripotent stem cells and their role in vaccine production: review article
Chick embryos are a great historical research model in basic and applied sciences. Along with other animal models, avian and specifically chicken embryo has been attended, as well. Avian fertilized eggs as a natural bioreactor are an efficient tool for producing recombinant proteins and vaccines manufacturing. Due to the limitations of birds' eggs for viral replication, avian stem cells culture...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cell
دوره 164 شماره
صفحات -
تاریخ انتشار 2016